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KMID : 0613820060160010156
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Journal of Life Science
2006 Volume.16 No. 1 p.156 ~ p.161
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Inhibitory Effects of the Essential Oil from Nardostachys jatamansi on Central Nervous System after Inhalation and Oral Administration
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Koo Byung-Soo
Kim Dae-Kun
Choi Jung-Hyun
Lee Dong-Woong
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Abstract
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The essential oil of Nardostachys jatamansi (Valerianaceae), which has been used for a long time in aroma therapy, was investigated after inhalation or oral administration for its analgesic effect, anticonvulsant action, hypnotic effect and in vitro inhibitory activity on monoamine oxidase. This fragrance oil showed a significant analgesic effect in the phenylquinone-induced writhing test, suppressed the convulsion induced by pentylenetetrazole and lengthened the pentobarbital-induced sleeping time in a time-dependent manner after fragrance inhalation or dose-independently by oral administration. Its inhibitory activity on monoamine oxidase was remarkable, showing 49.4% inhibition at a concentration of 5.0 ㎎/ml. Six new terpenes with seven known compounds were detected by our GC-MS analytical conditions used. As a result, the essential oil fragrance of Nardostachys jatamansi would be clinically useful for a sedative by either inhalation or oral administration.
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